Notre Dame held off Purdue for a 27-13 win Saturday afternoon. Photo via Notre Dame Athletics

Notre Dame 27, Purdue 13

The Irish held off the Boilermakers with a late touchdown and a pair of interceptions to thwart any hope of an upset in South Bend.

Jack Coan threw for 223 yards and two scores, Kyren Williams rushed for 91 yards and a 51-yard touchdown and Avery Davis had 120 yards receiving and a score for the Irish. Jackson Anthrop had seven catches for 90 yards for the Boilers, but Purdue, down just 20-13 in the fourth quarter, gave up the Williams score and then tossed two interceptions late to ice the game for the Irish.

Cincinnati 38, Indiana 24

The Hoosiers saw a 14-0 lead dissolve quickly as the No. 8 Bearcats handed IU its second loss in three weeks.

Michael Penix Jr. threw for 224 yards and two scores, but had three interceptions and the Hoosiers added another lost fumble to its card. The Bearcats countered with three rushing touchdowns, two from Jerome Ford, to get the road win.

Missouri 59, Southeast Missouri St. 28

The Tigers rolled up on its in-state opponent in Columbia.

Harrison Mevis hit his only field goal attempt from 43 yards and was 8-8 on extra point tries.

Missouri had 675 yards in the game and five passing touchdowns among the rout.

Wyoming 45, Ball State 12

The Cowboys cruised to a home win over the Cardinals Saturday afternoon.

Wyoming took a 31-0 lead and returned two interceptions for touchdowns. Carson Steele had 76 yards rushing and a touchdown for the Cardinals.